MRICD Protein Engineering Research Internship

Reference Code

MRDC-MRICD-2025-0009

How to Apply

All applications must be submitted through Zintellect at www.zintellect.com

The Department of Defense (DoD) is offering post bachelor's level internship at the U.S. Army Medical Research Institute of Chemical Defense (USAMRICD).

What will I be doing?

As an Oak Ridge Institute for Science and Education (ORISE) participant, you will join a community of scientists and researchers in an effort to focus on screening new enzymes in a variety of in vitro assays.

Why should I apply?

This research opportunity is currently available at the U.S. Army Medical Research Institute of Chemical Defense (USAMRICD), Defense Health Agency (DHA) in the field of protein engineering.  Mutant enzymes from human and bacterial sources will be analyzed for catalytic activities against a broad spectrum of organophosphorus compounds and other substrates.  As the selected candidate and under the guidance of a mentor, you will have laboratory opportunities which may include assessment of enzyme concentrations, characterization of enzyme size by polyacrylamide gel electrophoresis, characterization of polydispersive index (pdi) and hydrodynamic radius (Rh) using dynamic light scattering instruments, enzyme-based activity assays for developing kinetic constants, thermal denaturation experiments to assess enzyme stability. You will learn the process of around preparations for organophosphorus nerve agent hydrolysis assays, as well as other laboratory opportunities when available. Finally, you will be encouraged to present posters at scientific meetings. 

Where will I be located?

Aberdeen Proving Grounds, Maryland

What is the anticipated start date?

June 16, 2025.  Exact start dates will be determined at the time of selection and in coordination with the selected candidate. Applications are reviewed on an ongoing basis and internships or fellowships will be filled as qualified candidates are identified.

What is the appointment length?

Appointments are initially for one year with the option to extend the appointment for up to four additional years, contingent upon project needs and funding availability.

What are the provisions? 

You will receive a stipend to be determined by USAMRICD. Stipends are typically based on a participant’s academic standing, discipline, experience, and research facility location, the stipend range for this opportunity will be $54,750 - $59,900 for a 12-month appointment. Other provisions may include the following:

• Health Insurance Supplement (Participants are eligible to purchase health insurance through ORISE)
• Relocation Allowance
• Training and Travel Allowance