Metabolomics Research Associate (Contractor)

The Position:

The Drug Metabolism and Pharmacokinetics (DMPK) department at Genentech is seeking a highly motivated Metabolomics Scientist to join the Metabolomics team within the Bioanalytical (BA) group. Our team’s mission is to empower drug research, discovery and development process across Genentech by producing valuable, high-quality metabolomics & small molecule biomarker analysis through the use of cutting-edge technologies and high throughput workflows in support of biochemical assessments and biomarker discoveries.

Responsibilities:

• To develop and routinely employ bioanalytical methods for the qualitative and quantitative metabolomics & lipidomics analysis in various biological matrices using mass spectrometry to support biomarker research, discovery & development.
• Ability to develop and perform LC-HRMS based bioanalysis including sample preparation, as well as instrumental analysis and troubleshooting.
• Ability to perform global and targeted metabolomics & lipidomics data processing, statistical analysis, and data interpretation.
• Ability to collaborate and communicate with team members. Able to apply analytical skills and judgment in assessing the quality of assay data and assay performance.

Qualifications:

• Education: Bachelor or Master or PhD degree with relevant experience of 1-5 years.
• The candidate should have strong background in Bioanalytical Mass Spectrometry (LC-MS/MS and LC-HRMS) with hands on experience and proven ability to design, develop and routinely employ bioanalytical methods for the quantitative and qualitative analysis of endogenous small molecule metabolites.
• Hands-on experience in developing liquid chromatography assay and metabolite extraction and sample preparation techniques such as PP, LLE, SPE, Derivatization etc. The candidate will be preferred if having demonstrated mass spectrometry-based metabolomics & lipidomics experience.
• Prior experience with Shimadzu UHPLC, Sciex QTRAP, Thermo QE, and/or metabolomics lipidomics data analysis software tools will be desired.
• Experience with various LCMS data processing software such as XCMS, MS-DIAL, chromeleon, tracefinder, compound discoverer, analyst, multiquant is preferred.
• The candidate should be able to work independently in a fast-paced environment, as well as in a team setting. Strong organizational, communication and interpersonal skills.
• Ability to follow detailed verbal and written instructions. Must be self-motivated, able to multitask and meet timelines efficiently and productively.