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This position will be in support of the Department of Pharmacology at Uniformed Services University of the Health Sciences (USUHS) and the Armed Forces Radiobiology Research Institute (AFRRI). The particular research program includes analysis of the role of nucleic acid sensing pathways in the immune response to ionizing radiation and radioimmunopathogenesis at the cellular and organismal level. The incumbent will study the activity of pattern-recognition receptor-associated signaling, specifically the cGAS-STING and RIG-I/MDA5-MAVS axes, in response to ionizing radiation and radiation-related gene expression. The scope of work includes gene expression analysis with a particular interest in retroelement expression, analysis of cytokine profiles, intercellular communication, inflammatory and fibrosis markers. Laboratory experiments will be performed with human and murine macrophages, irradiated wild-type and transgenic mice. The effects of pharmacological modulators of specific pathways in response to pro- and anti-inflammatory signals and stress factors, including ionizing radiation will be analyzed.

Responsibilities
 

  • Assists in designing, developing, executing, and implementing scientific research and/or development.
  • Investigates the feasibility of applying a wide variety of scientific principles and theories to potential inventions and products.
  • Performs specialized laboratory research utilizing experimental protocols which involves specialized procedures.
  • Collects and handles samples and keeps detailed records of experiments.
  • Assists with the preparation of data for presentations at scientific meetings and for publication in journals.
  • May perform other duties and responsibilities as assigned or directed by the supervisor. This may include attendance of and participation in required training for role.

Qualifications

Education and Experience

  • Doctoral degree required. 
  • Biology, Biochemistry, Molecular Biology are preferred
  • Minimum of 0-5 years experience required.

Required Knowledge, Skills and Abilities

  • Knowledge of appropriate scientific area; ability to analyze and interpret data
  • Mice experience is highly preferred, must be okay with euthanasia
  • Cell culture molecular biology techniques
  • Bioinformatics skills preferred 
     
  • Ability to follow general instructions.
  • Good communication and analytical skills

Physical Capabilities 

  • Lifting: Requires lifting materials up to 25 lbs.
  • Ability to stand or sit at a computer for prolonged periods.
  • Ability to climb, pull, and lift heavy objects.