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Winter Co-op/DMPK Modeling

GSK
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Department Description:

Drug Metabolism & Pharmacokinetics (DMPK) Group is responsible for integrating the absorption, distribution, metabolism, and elimination (ADME) characteristics of drug candidate molecules from in vitro, pre-clinical and clinical information. More specifically DMPK Modelling group provides in vitro to in vivo translation, human dose predictions, and clinical using compartmental pharmacokinetics (PK) and physiologically based pharmacokinetics (PBPK) and pharmacodynamics (PD).

Job Description:

This position will allow the selected candidates to develop their PBPK and PKPD modeling skills in the DMPK modelling group. The PBPK scientist will have the opportunity to learn about PBPK and PKPD applications from early discovery to late-stage drug development for small and large molecules alike. Along with other DMPK team members, this scientist will collaborate across various cross-functional teams such as toxicology, biology, chemistry, clinical pharmacology, and formulations and will contribute to the application of model informed drug development strategies.

Responsibilities to include (but not limited to):

  • Independently build and validate PBPK and PKPD models to support evaluation of ADME properties for small/large molecules and/or new modalities.
  • Present modelling output in internal team and/or department meetings as well as the opportunity to publish any completed work.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.  

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). 

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. 

Minimum Qualifications:

  • Pursuing a MS or PhD in Mathematics, Pharmacology, Biochemistry, or other DMPK-related science disciplines.
  • Must be able to work full-time (35-40 hours/week) throughout the 6-month co-op (January ~ June 2025).
  • Must have an active student status and/or within 12 months post-graduation from a BS or MS degree program. Post-doctoral candidates are not eligible.

Preferred Qualifications:

  • Experience with application of PBPK softwares, e.g. SimCYP.
  • Basic Knowledge of DMPK processes in drug discovery and development.
  • Basic Understanding of the in vitro/ in vivo experiments used to describe general ADME principles especially drug absorption and drug distribution.
  • Scientific writing and presentation ability with excellent verbal communication skills.

Benefits:

  • While GSK embraces a flexible work environment, we do require certain positions to be onsite. Candidates who are hired for an on-site role or hybrid role, and reside outside of 50-miles from their assigned work location, are eligible for relocation stipend. This is a one-time payment to help offset housing & relocation expenses. Please refer to the position details for the requirements of each position. 
  • GSK Interns and Co-ops are offered a competitive hourly pay rate and benefits. Please note, benefits eligibility determined the month following date of hire.

Interested in learning more? Register now on our digital learning platform (GSK Get Ahead - Connectr) where you can access interview and assessment hints and tips, speak to a mentor and learn more about life at GSK.

Eligibility Requirements:

  • Must successfully pass a drug screen and background check prior to assignment target start date.  
  • If your skillsets are a match for this role, you will be contacted by our recruitment team with next steps to complete our internal World of GSK Assessment.
    • Please note, you must receive a passing score to move forward in the interview process. Once your assessment is complete, a recruiter will review your results and be in touch with next steps.
  • Please note this role is virtual.