2023 Cambridge Neuroimmunology Cell Biology Co-Op
The Future Talent Program features Cooperative (Co-op) education that lasts up to 6 months and will include one or more projects. These opportunities in our Research & Development Division can provide you with great development and a chance to see if we are the right company for your long-term goals.
The Neuroimmunology team is seeking a motivated and technically skilled individual with strong Neuroscience training to join our Cambridge-based team. Candidates will be able to work to collaborate with colleagues across diverse functional areas including genetics, chemical biology, immunology and pharmacology. Primary responsibilities include culturing of cell lines, primary and iPS-derived microglia to support the study of disease associated functions and phenotypes that will support identification and validation of novel therapeutic targets to treat Alzheimer’s disease, Parkinson’s disease and Amyotrophic Lateral Sclerosis (ALS).
The responsibilities of the Neuroimmunology COOP include: developing and performing disease-relevant cell-based functional assays and perform high content imaging, biochemical and molecular profiling techniques. The successful candidate will be able to communicate data clearly and concisely to the appropriate teams and stakeholders and thrive in a team environment.
Required Education & Experience:
- Candidates must be actively working towards or recent graduate with a BS/BA/MS or PhD degree in Biology, Neuroscience, Molecular Biology Bioengineering, Pharmacology, Biotechnology or equivalent degree
- Candidates must have strong general knowledge of Neuroscience
- Candidates must have experience in cell culture methods and sterile technique
- Candidates must have experience working with immortalized cells lines, primary rodent neurons and glia (e.g. microglia). human iPS-derived CNS cell models including microglia and neurons.
- Candidates must have understanding of standard cell transfection techniques using lipid-based and electroporation methodology
- Candidates must have cell staining methods including Immunofluorescence and cell masks or cell structural staining methods
- Candidates must have some experience with method optimization, troubleshooting and strong critical thinking skills
- Candidates must have working knowledge of image acquisition and microscopy and strong working knowledge of mouse neuroanatomy
- Candidates must have the ability to work independently on data analysis including a practical knowledge of statistics
Preferred Experience & Skills:
- Candidate should be proactive and strong independent learner
- Candidates should be able to demonstrate experience with quantitative image analysis
- Candidates should have knowledge of application of CRIPSR editing technology and siRNA knockdown strategies
- Candidates should have worked understanding of biochemical and molecular biology techniques including protein and RNA extraction, quantitation and detection methods such as western-blot, ELISA and qPCR, RNAseq concepts and methods
- Candidates should have experience with cellular signaling and functional studies including phagocytosis and/or cell motility measures
- Candidates should have strong oral, written and presentation skills with ability to explain concepts clearly in lab and small team settings
We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.