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Senior/Principal Scientist, Biophysics

We are looking to add a biophysicist to our growing drug discovery team as we identify and develop novel, natural product-inspired therapeutics to address serious illnesses in multiple therapeutic indications. As a key member of our high-performing drug discovery team, the ideal candidate will design, develop, and execute biophysical assays to identify the molecular targets recognized by Hexagon Bio-produced metabolites. Subsequently, the successful candidate will be involved in the characterization of optimized molecules as metabolite hits to advance clinical candidates. On a daily basis, the biophysicist will have an opportunity to work with a motivated team of synthetic biologists, natural product chemists, biologists, and medicinal chemists who collaborate to develop innovative approaches to identify novel therapeutics. Additional responsibilities include documenting, analyzing and interpreting experiments, and presenting results within a multidisciplinary team environment.

Key Qualifications: 
  • PhD in biophysics, biochemistry, or related discipline + 5 years of relevant experience
  • Experience and/or familiarity with:
  • Mass spectrometry-based assays such as AS-MS to characterize protein-small molecule binding
  • Biophysical assays such as fluorescence polarization, ITC, NMR, SPR, DSF, MST
  • Relatively high throughput assays, such as TR-FRET, AlphaScreen
  • Skilled with binding kinetics, target occupancy, and modes of inhibition
  • Rigorous and detail-oriented experimentalist with an understanding of statistics
  • Outstanding communication skills with the ability to build transparent and collaborative relationships across the company 
  • Exceptional interpersonal and management skills that foster collaboration, teamwork, scientific excellence, and innovation
  • Experience in drug discovery is a plus

What We Offer:
  • A flexible and dynamic work environment where you pave your own path, Hexagon cultivates employees' unique strengths at all levels and provides mobility across departments.
  • Weekly “All Hands Meetings” provide an opportunity to share company and team updates. These meetings are rooted in our value of transparency. They are designed to foster a culture of collaboration, curiosity, and open communication.
  • Competitive compensation and a robust benefits package: a comprehensive suite of medical, dental, and vision insurance plans through TriNet, which offers additional voluntary benefits (pet insurance, accident insurance, home & auto insurance, and more).
  • Equity and a 401(k) plan.
  • Rapid career advancement for driven performers.
  • Access to scientific conferences all over the country throughout the year.
  • A range of amenities, courtesy of the Menlo Park Labs business park, including shuttle, gym, rock-climbing wall, pool, sports courts, cafe, bike lockers, and free EV charging stations.
  • Opportunities to engage with the Hexagon community through team-building events like our monthly Hexagon Happy Hour and holiday parties.

Hexagon Bio is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race, color, ethnicity, veteran status, religion, national origin, marital status, political affiliation, age, sex, sexual orientation, disability status, membership in an organization, or any other non-merit factors.