Biologics Associate III
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.
This position is responsible for all aspects of product production, from cell culture scale up through production in bioreactors (or other technologies) to product purification. Products include biological therapeutics such as monoclonal antibodies, plasmids and viral vectors for clinical research use. Evening and/or weekend work may occasionally be required based on project need.
- Scale up of cell culture and purification procedures from research levels to production levels
- Developing purification schema appropriate to each product
- Adapt alternative technologies to support production activities
- Train and mentor personnel, including cross training to provide backup capabilities
- Assist Management with the development of documentation for resource operations, including batch records and standard operating procedures
- Monitor and maintain equipment including autoclaves, bioreactors, incubators and chromatography equipment
- Assist with facility cleaning, culture vessel de-pyrogenation, assembly and sterilization
- Interface with and assist Quality Control in coordinating product testing and facility monitoring
- Demonstrate technical acumen, operational understanding and GMP compliance in the maintenance and continued expansion of the Biologics Processing Facility
- Support the improvement and implementation of all GMP procedures and policies related to manufacturing operations
- Maintain a high level of quality and safety standards
- Analyze and evaluate the effectiveness of manufacturing methods, costs and results
- Maintains appropriate level of training and meets compliance standards
- Bachelor’s degree in Biology, Chemistry or related scientific major or equivalent
- Experience in aseptic processing techniques and a thorough understanding of biologics clinical manufacturing required
- Thorough understanding of cGMP requirements for clinical manufacturing
- Ability to work with limited supervision and to handle problems of a more difficult nature
- Excellent communication skills, both oral and written
- Ability to accurately and reproducibly perform arithmetic calculations including fractions, decimals and percentages and basic algebraic and geometric calculations
- Experience with protein purification
- Familiarity with multiple technologies for culture of mammalian and prokaryotic (bacterial cell culture; fermentation) cells at various scales of production
- Experience with DNA plasmid prep and viral vector production
- High level of comfort in dealing with specialized mechanical and electronic equipment
- Familiarity with disposable technologies such as Single Use Bioreactors (SUB)
A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.
Our Commitment to Diversity
We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at firstname.lastname@example.org or by calling 206-667-4700.