Oncology Drug Discovery, Biochemistry Internship

10-12 week paid internship

Individual will be responsible for working with scientists in the drug discovery group, contributing to

biochemical assays including enzyme kinetics as well as understanding the MOA of lead drug candidates

of some of the key projects. The successful internship candidate will be trained to independently perform

experiments using variety of biochemical techniques utilizing recombinant proteins/enzymes.

This position is for an undergraduate biochemistry major looking to gain laboratory experience in an

industrial setting. As a member of the Discovery Chemistry team, he/she will contribute to the synthesis

of a unique compound library.

Principal Duties and Responsibilities:

 Independently execute experiments in the lab with minimal supervision.

 Analyze and interpret data using scientific analysis and statistical software.

 Provide support to other studies driven by in vivo and pharmacology scientists.

 Summarize and present findings to the research department meetings.

 Maintain detailed records of all experiments in a laboratory notebook.

 Explore activity and mechanism of drug combinations in preclinical cancer models

 Familiarity with basic biology techniques to characterize drug combination activity (e.g. mammalian

cell culture, immunoblot, protein/RNA/DNA extraction, PCR) preferred

 Communicate research results to supervisor in an accurate and timely manner.

 Participate in research group and project meetings

 Maintain high standards of laboratory safety in compliance with the H3 safety manual

Job Qualifications:

 Completed lab-based coursework in chemistry, molecular biology, and biochemistry

 Undergraduate chemistry major with a strong academic record.

 Must have completed two semesters of organic chemistry including laboratory coursework.

 Preference given to candidates who have performed independent undergraduate research as well.

 Familiar with standard analytical techniques (NMR, TLC, HPLC, mass spectroscopy)

 Excellent communication skills, work ethic, and organizational skills

 Experience with ChemDraw, Powerpoint and Excel preferred

 Strong desire to learn more about drug discovery and cancer biology

H3 Biomedicine Inc. is a privately-held, uniquely-structured oncology discovery enterprise whose sole

mission is to become a prolific source of new drugs that treat more human cancers with greater success.

H3B is applying the expertise of leading scientists to the integration of insights from cancer genomics

with innovative capabilities in synthetic chemistry and tumor biology to pursue the most promising

current opportunity in cancer therapeutics: patient-based, genomics-driven, small molecule drugs