You are viewing a preview of this job. Log in or register to view more details about this job.
Email

Research Associate I/II- Sellers Lab, Therapeutic Target Discovery and Validation Team 

 

JOB DESCRIPTION

The Broad Institute of Harvard and MIT is looking for an exceptional candidate for a unique RA position. The Broad Institute of MIT and Harvard is a non-profit biomedical research enterprise that is empowering a revolution in biomedicine to accelerate the pace at which the world conquers disease. Founded in 2004 by Eric Lander and philanthropists Eli and Edythe L. Broad, the Broad Institute includes faculty, professional staff, and students from throughout the MIT and Harvard biomedical research communities and beyond, with collaborations spanning more than a hundred private and public institutions in more than 40 countries worldwide. The Broad Institute provides a vibrant research environment with close links to top academic institutions across the Boston area and beyond.

 

OVERALL RESPONSIBILITY

The successful candidate will join a multidisciplinary research team focused on developing technologies and strategies for cancer target discovery and therapeutic development. The role centers on the characterization of novel cancer vulnerabilities and the experimental evaluation of therapeutic strategies to modulate them. The RA will contribute to experimental efforts that integrate molecular biology, chemical biology, and computational analyses for target validation and drug discovery. Following an initial training period, the candidate is expected to work independently in executing experiments while actively contributing to experimental design and project planning. Collaboration is a key aspect of this position, requiring regular interaction with other scientists across different research teams and with external collaborators. The individual will also be responsible for the effective communication of scientific findings, both verbally and in writing, contributing to collaborative research activities and inter-group communications.

 

PRINCIPAL DUTIES AND RESPONSIBILITIES

  • Learn and help develop pipelines of mammalian tissue culture and phenotypic readouts using genetic and small molecule perturbations.
  • Apply compound target engagement and protein interaction displacement assays in cells.
  • Assist with recombinant protein expression, purification, quality and quantity assessment, and in vitro assays analyzing small molecule – protein interactions.
  • Aid with bioinformatic analysis of existing datasets, such as DepMap and others, to identify novel oncogenic targets for potential therapeutic intervention.
  • Operate and maintain laboratory equipment to complete investigations.
  • Document, compile, and analyze experimental data. Report data to team in oral and written reports.
  • Attend team meetings and contribute to experimental planning.
  • Maintain and improve technical knowledge base.
  • Other related tasks as required.

 

REQUIREMENTS

Education

  • Bachelor or master’s degree in the life sciences 0-1 years of experience.
  • Prior cell biology, molecular biology, and chemistry coursework.

 

Skills and abilities

  • Familiarity with general molecular and cell biology techniques, including mammalian cell and tissue culture, is strongly desired.
  • Experience with protein expression and purification is a plus.
  • Experience with basic bioinformatic analyses using R or Python is a plus.
  • Exceptional organizational and critical thinking skills, lab notebook practices and attention to detail are critically essential.
  • Excellent communication skills and the ability to interact with all levels of staff are needed.
  • Ability to handle a variety of tasks in a fast-paced environment, large complex experiments, and large data sets, all of which demand great attention to detail.         

 

The Broad Institute provides a vibrant research environment with close links to top academic institutions across the Boston Area, and provides the potential for the associate’s contributions to be used and recognized worldwide. The Broad Institute will not offer visa sponsorship for this opportunity. Start date: present - July 2026.