Research Associate: Broad Institute of MIT/Harvard (Golub Lab)

Research Associate I – The Golub Lab

The Broad Institute of MIT and Harvard

The Golub Lab at the Broad Institute of MIT and Harvard is looking for an outstanding Research Associate (RA) I to join our team. We are a group of passionate scientists and physician-scientists working at the forefront of functional genomics and cancer biology. Our mission is to develop novel therapeutic strategies for patients with cancer.

Our Ideal Candidate:

We are seeking a highly motivated, coachable, and intellectually curious individual who is ready to take on an exciting project. While you will work under the close guidance of a senior physician-scientist, we expect you to be more than a passive participant. We are looking for a relentless problem-solver who takes initiative within our ongoing research, anticipates experimental needs, and actively proposes solutions based on the scientific literature.

This is the perfect position for a recent life sciences graduate who is planning to pursue further MD/PhD or PhD training, and wants to spend their time before grad school deeply involved in high-impact, rigorous science.

The Environment:

Your hard work will directly accelerate ongoing research efforts to develop novel therapeutic strategies for patients with difficult-to-treat hematologic malignancies. You will become adept in multiple wet-lab techniques related to functional genomics (mammalian cell culture, CRISPR genetic engineering), and chemical biology/pharmacology. We place a major emphasis on developing your sense of scientific rigor and expanding your capacity for scientific creativity within a highly supportive, team-driven environment. The Broad Institute provides a vibrant research setting with close links to top academic institutions across the Boston Area and provides the potential for individuals’ contributions to be used and recognized worldwide.

Our Commitment to Your Career Development:

We view this role as a launchpad for your career as a future physician or scientist. You will work directly alongside a senior physician-scientist, acting as a crucial driver for their active projects. At the same time, you will gain access to a network of highly accomplished researchers at the Broad with various affiliations at cancer hospitals in Boston. We will actively mentor your transition to medical or graduate school based on the initiative and achievement you demonstrate in this role. By working daily with a physician-scientist, you will gain a firsthand understanding of translational medicine and what it takes to bridge the gap between bench and bedside.

Role Expectations:

• Work closely with your scientific mentor to plan experiments, develop new protocols, and carry out benchwork in a timely fashion to accelerate project timelines.
• Receive targeted initial training to rapidly build the skills needed to execute and optimize complex experiments that support the overarching project goals.
• Become adept in common wet-lab experiments related to cell culture, protein biochemistry, pharmacology, and cloning.
• Become adept in large-scale mammalian cell culture systems including high-throughput functional genomics screens.
• Proactively review scientific literature pertinent to the project and propose well-reasoned approaches to overcome experimental hurdles.
• Operate and maintain laboratory equipment as needed.
• Prepare, order, and maintain stocks of necessary reagents and supplies.
• Document, compile, and analyze experimental data as part of a detailed and timely lab notebook.
• Attend team meetings, present results, and help plan upcoming phases of the project.

Minimum Qualifications:

• BS degree in Biology, Biochemistry, Genetics, or related field required.
• Prior experience working in a scientific research setting is strongly desired.
• Prior experience working with mammalian cell culture is strongly desired.
• Exceptional initiative, strong motivation, and a meticulous, systematic approach to detail are essential for this role.
• Strong interpersonal, communication, organizational, and time-management skills.
• Familiarity with molecular biology, recombinant DNA, and protein biochemistry are strongly desired. Familiarity with flow cytometry is a plus but not required.
• Background in computer science or bioinformatics (R, MATLAB, Python) and basic understanding of using AI tools to develop code is a plus.
• Willing to commit to 2-3 years in the lab.

Your next steps:

• Email us with a cover letter and your CV to TRGapplications@broadinstitute.org