Tumor Biology Co-Op

Incyte is a biopharmaceutical company focused on the discovery, development, and commercialization of novel medicines to meet serious unmet medical needs in oncology and inflammation and autoimmunity. Incyte is committed to the rigorous pursuit of research and development excellence to improve the lives of patients, make a difference in health care, and build sustainable value. 

The Company strives to discover and develop first-in-class and best-in-class medicines-advancing a diverse portfolio of large and small molecules.

Tumor Biology Co-Op 

The Tumor Biology department is interested in hosting a lab-based co-op position at Incyte based in Wilmington in building 1801. 

The candidate will primarily focus on assay design and development as well answering key biology questions for target discovery, identification and validation using a range of in vitro systems focused on progressing degrader-based modalities. 

Job responsibilities

• Utilize appropriate in vitro based cell line models to evaluate effectiveness of tool inhibitors and degraders to help validate potential screening cell lines
• Determine correlation between degree of protein degradation and functional effects 
• Establish functionally relevant PD markers that correlate with protein degradation and cell viability in dependent cell lines
• Address toxicity concerns of target inhibition in normal cell models
• Understand functional and pharmacodynamic effects of inhibiting the target through different therapeutic modalities
• Collaborate with members of the Tumor Biology team as well as other departments including Translational Medicine, Chemistry, Biochemistry, Screening and Structural Biology teams.   
• Analyze data and present to members of the research team at internal group meetings.

Requirements for position 

• A background in Biology or relevant discipline with an enthusiasm for drug discovery 
• Strong experience in vitro assays including cell culture, western blot, PCR and sterile technique and proliferation/viability assays 
• Preferred experience in use of genetically engineered cell lines used in drug development such as HiBiT and NanoBRET and knowledge of cancer biology. 
• Understanding of live-cell imaging techniques such as IncuCyte and IncuCyte capabilities including, cell proliferation, cytotoxicity assays, co-culture, and antibody-free labelling with photosensitive dyes. 

What you will gain 

• Hands on lab-based experience in medicinal research to develop novel therapies.
• Company-wide interactions and cross department collaboration strategies with an emphasis on the value of a high performing set of teams to accomplish a common goal. 
• An understanding of current standards of care in cancer treatments and the discovery science in industry which leads to the evolution of new groundbreaking therapies.
• The assays used and questions asked in the discovery and development of cancer therapies including biology validation, PK/PD studies, mitigation of potential toxicities, clinical guidance and being aware of competitive landscapes.