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Job Description:

  • We are currently seeking a highly motivated and passionate scientist in exploratory biologics to join our team in the Immunology Discovery department based in Cambridge MA. The candidate will focus on making therapeutic molecules using recombinant DNA technology, expression/purification of recombinant proteins, testing purified proteins in functional cellular assays, including basic cell biology and biochemical skills.
  • The position offers a unique opportunity for a talented scientist to work in a dynamic, innovative, and multi-disciplinary environment to develop their career at the interface of basic research and early drug discovery.
  • The scientist will be responsible for conceptualization, designing strategies to make therapeutic reagents, execution and analysis with the overall aim of promoting innovative drug discovery. The position requires ability to work independently, have excellent technical, written and oral communication skills and work very well in a collaborative team environment.

Requirements:

  • The applicant must have a bachelor's degree or master's degree in Biological Science or related field with 2-3 years of job-related experience.
  • Extensive hands-on experience in recombinant DNA technology, design, expression and purification of recombinant monoclonal antibodies.
  • Motivated to execute well-thought and well-planned in vitro experiments using the tool reagents generated.
  • Hands-on experience in multi-colour flow cytometry with both, handling flow cytometer (Canto, MACS Quant) and independently analysing the data using analytical software such as Flowood is required.
  • Proficient in carrying out ELISA/MSD to quantitate pro-inflammatory proteins.
  • Basic cell biology and biochemical skills: Tissue culture, Transfection, Cell line generation, SDS-PAGE, Immunoprecipitation, Western blotting etc.
  • Knowledge of DNA/RNA handling and other molecular biology techniques like PCR and qPCR.
  • Hands-on experience in carrying out size exclusion chromatography (SEC) and mass spectrometry.